{"entity":{"id":"paper-onetest-algorithm-taiwan-cancers-2020","kind":"paper","name":"Improving Multi-Tumor Biomarker Health Check-Up Tests with Machine Learning Algorithms","aka":[],"tldr":"The Taiwanese study behind OneTest's algorithm: in 27,938 people having routine tumour-marker check-ups, a machine-learning score separated those later diagnosed with cancer only moderately well.","summary":"Wang and colleagues (Chang Gung Memorial Hospital, Linkou, Taiwan, with 20/20 GeneSystems) developed sex-specific cancer screening algorithms and an organ-of-origin algorithm from tumour-marker values, age and sex of 27,938 asymptomatic people screened at a Taiwanese medical centre between May 2001 and April 2015, 342 of whom were later confirmed to have cancer, with external validation at a second centre. The area under the curve was 0.8736 for men and 0.6938 for women in external cross validation. The organ-system algorithm had 81.2% sensitivity and 64.9% specificity for men and 81.7% and 67.5% for women. The authors' disclosure states that 20/20 GeneSystems is commercialising the algorithms under the OneTest brand.","asOf":"2026-11-03","links":[{"label":"Cancers 2020","url":"https://doi.org/10.3390/cancers12061442"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/32492934/"},{"label":"Wu et al., Computers in Biology and Medicine 2022 (LSTM model on 163,174 people)","url":"https://doi.org/10.1016/j.compbiomed.2022.105362"}],"tags":[],"related":[],"cancers":[],"sections":["early-detection"],"technologies":["mced","proteomics"],"targets":[],"drugs":["onetest"],"companies":["2020-biolabs"],"institutions":["chang-gung-memorial-hospital"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["cancers-mdpi"],"dependsOn":[],"notes":[],"journal":"Cancers","year":2020,"doi":"10.3390/cancers12061442","pmid":"32492934","authors":"Wang HY, Chen CH, Shi S, Chung CR, et al.","paperType":"observational","findings":["Area under the curve in external validation: 0.87 for men, 0.69 for women.","Organ-system algorithm: about 81% sensitivity at 65 to 68% specificity."],"whatItMeans":"An area under the curve of 0.69 for women is weak discrimination; the paper reports risk groups rather than a positive predictive value, so it does not show how many positive OneTest results are cancer.","caveats":["Retrospective real-world data from health check-ups, with only 342 cancers.","Authors are affiliated with or own stock in 20/20 GeneSystems."],"changedPractice":false,"participants":27938},"route":"/key-papers/paper-onetest-algorithm-taiwan-cancers-2020/","neighbours":{"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"}],"technology":[{"id":"mced","kind":"technology","name":"Multi-cancer early detection (MCED)","route":"/technologies/mced/"},{"id":"proteomics","kind":"technology","name":"Proteomics & phosphoproteomics","route":"/technologies/proteomics/"}],"drug":[{"id":"onetest","kind":"drug","name":"OneTest for Cancer","route":"/drugs/onetest/"}],"company":[{"id":"2020-biolabs","kind":"company","name":"20/20 BioLabs","route":"/companies/2020-biolabs/"}],"institution":[{"id":"chang-gung-memorial-hospital","kind":"institution","name":"Chang Gung Memorial Hospital","route":"/institutions/chang-gung-memorial-hospital/"}],"journal":[{"id":"cancers-mdpi","kind":"journal","name":"Cancers","route":"/journals/cancers-mdpi/"}]}}