{"entity":{"id":"paper-onken-uveal-melanoma-gene-expression-coog-ophthalmology-2012","kind":"paper","name":"Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma","aka":[],"tldr":"A prospective study in 459 people with eye melanoma confirming that a gene-activity test separates a low-risk class from a high-risk class for spread.","summary":"Metastasis was detected in 3 class 1 cases (1.1 per cent) and 44 class 2 cases (25.9 per cent).","asOf":"2026-11-04","links":[{"label":"Onken et al., Ophthalmology 2012","url":"https://doi.org/10.1016/j.ophtha.2012.02.017"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/22521086/"}],"tags":[],"related":[],"cancers":["uveal-melanoma"],"sections":["diagnostics"],"technologies":["gene-expression-prognostic-assays"],"targets":[],"drugs":["decisiondx-um"],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Ophthalmology","year":2012,"doi":"10.1016/j.ophtha.2012.02.017","pmid":"22521086","authors":"Onken MD, Worley LA, Char DH, et al.","paperType":"translational","findings":["Metastasis in 1.1% of class 1 and 25.9% of class 2 cases."],"whatItMeans":"The class guides how closely the liver is watched after treatment of the eye.","caveats":["Follow-up shorter than the time over which many metastases appear."],"participants":459},"route":"/key-papers/paper-onken-uveal-melanoma-gene-expression-coog-ophthalmology-2012/","neighbours":{"cancer":[{"id":"uveal-melanoma","kind":"cancer","name":"Uveal melanoma","route":"/cancers/uveal-melanoma/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"gene-expression-prognostic-assays","kind":"technology","name":"Gene-expression prognostic assays","route":"/technologies/gene-expression-prognostic-assays/"}],"drug":[{"id":"decisiondx-um","kind":"drug","name":"DecisionDx-UM","route":"/drugs/decisiondx-um/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}