{"entity":{"id":"paper-peinado-nat-rev-cancer","kind":"paper","name":"Pre-metastatic niches: organ-specific homes for metastases","aka":[],"tldr":"Paper cited by one pathway page, indexed on Europe PMC as PubMed record 28303905 and published in Nature Reviews Cancer; the citing page links this DOI, which is how the record was matched.","summary":"It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.\n\nIndexed on Europe PMC as PubMed record 28303905 (DOI 10.1038/nrc.2017.6). Matched by DOI alone: one pathway page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.","asOf":"2026-09-22","links":[{"label":"Nat Rev Cancer 2017","url":"https://doi.org/10.1038/nrc.2017.6"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/28303905/"},{"label":"Europe PMC","url":"https://europepmc.org/article/MED/28303905"}],"tags":["europepmc-ingest"],"related":["pre-metastatic-niche"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nature-reviews-cancer"],"dependsOn":[],"notes":[],"journal":"Nature Reviews Cancer","year":2017,"doi":"10.1038/nrc.2017.6","pmid":"28303905","authors":"Peinado H, Zhang H, Matei IR, et al.","paperType":"review","findings":[],"whatItMeans":"One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.","caveats":["Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper."]},"route":"/key-papers/paper-peinado-nat-rev-cancer/","neighbours":{"pathway":[{"id":"pre-metastatic-niche","kind":"pathway","name":"The pre-metastatic niche","route":"/pathways/pre-metastatic-niche/"}],"journal":[{"id":"nature-reviews-cancer","kind":"journal","name":"Nature Reviews Cancer","route":"/journals/nature-reviews-cancer/"}]}}