{"entity":{"id":"paper-persson-myb-nfib-pnas-2009","kind":"paper","name":"Recurrent fusion of MYB and NFIB transcription factor genes in adenoid cystic carcinoma","aka":[],"tldr":"This study discovered that adenoid cystic carcinomas of the salivary gland and breast are driven by a fusion of the MYB and NFIB genes, providing the defining molecular feature of the tumour and a diagnostic marker.","summary":"Molecular study identifying a recurrent t(6;9) translocation in adenoid cystic carcinoma that fuses the MYB oncogene to NFIB, leading to MYB overexpression by loss of microRNA-mediated repression, present in the majority of tumours of both head and neck and breast origin.","asOf":"2026-09-17","links":[{"label":"Proc Natl Acad Sci U S A 2009","url":"https://doi.org/10.1073/pnas.0909114106"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/19841262/"}],"tags":[],"related":[],"cancers":["adenoid-cystic-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["pnas"],"dependsOn":[],"notes":[],"journal":"Proceedings of the National Academy of Sciences","year":2009,"doi":"10.1073/pnas.0909114106","pmid":"19841262","authors":"Persson M, Andrén Y, Mark J, et al.","paperType":"basic","findings":["MYB-NFIB fusion detected in the majority of adenoid cystic carcinomas.","Fusion leads to MYB overexpression through loss of 3' untranslated region regulation."],"whatItMeans":"MYB immunostaining and MYB-NFIB fusion testing are now diagnostic tools for adenoid cystic carcinoma, and MYB is the principal target of therapeutic research in the disease.","caveats":["No approved MYB-directed therapy has yet followed."],"changedPractice":true},"route":"/key-papers/paper-persson-myb-nfib-pnas-2009/","neighbours":{"cancer":[{"id":"adenoid-cystic-carcinoma","kind":"cancer","name":"Adenoid cystic carcinoma","route":"/cancers/adenoid-cystic-carcinoma/"}],"journal":[{"id":"pnas","kind":"journal","name":"Proceedings of the National Academy of Sciences","route":"/journals/pnas/"}]}}