{"entity":{"id":"paper-schmid-placental-site-trophoblastic-tumour-outcomes-lancet-2009","kind":"paper","name":"Prognostic markers and long-term outcome of placental-site trophoblastic tumours: a retrospective observational study","aka":[],"tldr":"The largest series of this rare trophoblastic tumour showed that women whose tumour appeared four or more years after the causative pregnancy did badly whatever the treatment, and that early-stage disease is cured by hysterectomy alone.","summary":"Retrospective study of 62 women with placental-site trophoblastic tumour treated in the UK trophoblastic disease centres from 1976 to 2006.\n\nTen-year overall survival was about 70 percent; stage I disease was cured by hysterectomy without chemotherapy, stage II to IV disease required platinum-based chemotherapy (EP/EMA), and an interval of 48 months or more since the antecedent pregnancy was the strongest adverse prognostic factor, with almost no long-term survivors in that group.","asOf":"2026-09-18","links":[{"label":"Lancet 2009","url":"https://doi.org/10.1016/S0140-6736(09)60618-8"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/19552948/"}],"tags":[],"related":[],"cancers":["placental-site-trophoblastic-tumour"],"sections":[],"technologies":[],"targets":[],"drugs":["etoposide","cisplatin"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["lancet"],"dependsOn":[],"notes":[],"journal":"The Lancet","year":2009,"doi":"10.1016/S0140-6736(09)60618-8","pmid":"19552948","authors":"Schmid P, Nagai Y, Agarwal R, et al.","paperType":"observational","findings":["Ten-year overall survival about 70 percent; hysterectomy alone cured stage I disease.","Interval of 48 months or more from the antecedent pregnancy predicted death from disease regardless of treatment."],"whatItMeans":"Placental-site trophoblastic tumour is managed by hysterectomy for early disease and platinum chemotherapy for advanced disease, and the interval since pregnancy identifies women who need intensified or experimental treatment.","caveats":["Retrospective series over thirty years with changing treatments.","Numbers in the poor-prognosis group were small."],"changedPractice":true,"participants":62},"route":"/key-papers/paper-schmid-placental-site-trophoblastic-tumour-outcomes-lancet-2009/","neighbours":{"cancer":[{"id":"placental-site-trophoblastic-tumour","kind":"cancer","name":"Placental-site trophoblastic tumour and epithelioid trophoblastic tumour","route":"/cancers/placental-site-trophoblastic-tumour/"}],"drug":[{"id":"cisplatin","kind":"drug","name":"Cisplatin","route":"/drugs/cisplatin/"},{"id":"etoposide","kind":"drug","name":"Etoposide","route":"/drugs/etoposide/"}],"journal":[{"id":"lancet","kind":"journal","name":"The Lancet","route":"/journals/lancet/"}]}}