{"entity":{"id":"paper-seiler-bladder-molecular-subtypes-chemotherapy-eur-urol-2017","kind":"paper","name":"Impact of Molecular Subtypes in Muscle-invasive Bladder Cancer on Predicting Response and Survival after Neoadjuvant Chemotherapy","aka":[],"tldr":"A study that sorted muscle-invasive bladder cancers into molecular types from gene activity and found that the basal type gained most from chemotherapy before surgery.","summary":"A single-sample genomic subtyping classifier predicted four consensus molecular subtypes with 73 per cent accuracy, and patients with basal tumours showed the most improvement in overall survival with neoadjuvant chemotherapy.","asOf":"2026-11-04","links":[{"label":"Seiler et al., Eur Urol 2017","url":"https://doi.org/10.1016/j.eururo.2017.03.030"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/28390739/"}],"tags":[],"related":[],"cancers":["muscle-invasive-bladder-cancer"],"sections":["diagnostics"],"technologies":["gene-expression-prognostic-assays"],"targets":[],"drugs":["decipher-bladder"],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"European Urology","year":2017,"doi":"10.1016/j.eururo.2017.03.030","pmid":"28390739","authors":"Seiler R, Ashab HAD, Erho N, et al.","paperType":"translational","findings":["Subtype classifier accuracy 73%.","Basal tumours: most overall survival improvement with neoadjuvant chemotherapy."],"whatItMeans":"Molecular type may help choose who benefits most from chemotherapy before bladder removal.","caveats":["Retrospective; the abstract does not name the commercial product."]},"route":"/key-papers/paper-seiler-bladder-molecular-subtypes-chemotherapy-eur-urol-2017/","neighbours":{"cancer":[{"id":"muscle-invasive-bladder-cancer","kind":"cancer","name":"Muscle-invasive and advanced bladder cancer","route":"/cancers/muscle-invasive-bladder-cancer/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"gene-expression-prognostic-assays","kind":"technology","name":"Gene-expression prognostic assays","route":"/technologies/gene-expression-prognostic-assays/"}],"drug":[{"id":"decipher-bladder","kind":"drug","name":"Decipher Bladder","route":"/drugs/decipher-bladder/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}