{"entity":{"id":"paper-sempet-de-santis-jco-2004","kind":"paper","name":"SEMPET: FDG-PET as a predictor of viable tumour in post-chemotherapy seminoma residuals","aka":[],"tldr":"A PET scan reliably told apart residual masses that still contained living seminoma from scar tissue after chemotherapy, allowing surgeons to leave PET-negative masses alone rather than operating on all masses over 3 cm.","summary":"Prospective multicentre study of 51 patients with metastatic seminoma and residual masses after chemotherapy who underwent FDG-PET, with results validated against histology or clinical follow-up.\n\nPET had a sensitivity of 80 percent and specificity of 100 percent for viable tumour, and for residual lesions over 3 cm specificity and sensitivity were both 100 percent, outperforming CT size criteria.","asOf":"2026-09-17","links":[{"label":"J Clin Oncol 2004","url":"https://doi.org/10.1200/JCO.2004.07.188"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/15020605/"}],"tags":[],"related":[],"cancers":["seminoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["jco"],"dependsOn":[],"notes":[],"journal":"Journal of Clinical Oncology","year":2004,"doi":"10.1200/JCO.2004.07.188","pmid":"15020605","authors":"De Santis M, Becherer A, Bokemeyer C, et al.","paperType":"observational","findings":["Specificity 100 percent, sensitivity 80 percent for viable residual seminoma.","Sensitivity and specificity 100 percent for lesions over 3 cm."],"whatItMeans":"FDG-PET is standard for residual seminoma masses larger than 3 cm after chemotherapy, sparing most men surgery.","caveats":["Small study; false positives occur when PET is done too soon after chemotherapy, so scans are delayed at least six weeks."],"changedPractice":true,"participants":51},"route":"/key-papers/paper-sempet-de-santis-jco-2004/","neighbours":{"cancer":[{"id":"seminoma","kind":"cancer","name":"Seminoma","route":"/cancers/seminoma/"}],"journal":[{"id":"jco","kind":"journal","name":"Journal of Clinical Oncology","route":"/journals/jco/"}]}}