{"entity":{"id":"paper-siegel-crc-incidence-1974-2013-jnci-2017","kind":"paper","name":"Colorectal cancer incidence patterns in the United States, 1974 to 2013","aka":[],"tldr":"Analysing four decades of US registry data, this study showed colorectal cancer incidence rising steeply in adults under 50 while falling in older adults, with people born around 1990 having double the colon cancer risk and quadruple the rectal cancer risk of those born around 1950.","summary":"Age-period-cohort analysis of colorectal cancer incidence from SEER registries between 1974 and 2013, showing increases of 1 to 2 percent per year in adults aged 20 to 39 and rising rectal cancer incidence in those aged 40 to 54, alongside declines in adults 55 and older attributed to screening.","asOf":"2026-09-17","links":[{"label":"J Natl Cancer Inst 2017","url":"https://doi.org/10.1093/jnci/djw322"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/28376186/"}],"tags":[],"related":[],"cancers":["early-onset-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["jnci"],"dependsOn":[],"notes":[],"journal":"JNCI: Journal of the National Cancer Institute","year":2017,"doi":"10.1093/jnci/djw322","pmid":"28376186","authors":"Siegel RL, Fedewa SA, Anderson WF, et al.","paperType":"observational","findings":["Colon cancer incidence rising 1 to 2.4 percent per year in adults aged 20 to 39 since the mid-1980s.","Rectal cancer incidence rising about 3.2 percent per year in adults aged 20 to 29 and 30 to 39."],"whatItMeans":"This is the paper that made early-onset colorectal cancer a public health issue and drove the change in screening age.","caveats":["Registry analysis cannot identify causes.","Some increase may reflect greater detection through colonoscopy for symptoms."],"changedPractice":true},"route":"/key-papers/paper-siegel-crc-incidence-1974-2013-jnci-2017/","neighbours":{"cancer":[{"id":"early-onset-colorectal","kind":"cancer","name":"Early-onset colorectal cancer (under 50)","route":"/cancers/early-onset-colorectal/"}],"journal":[{"id":"jnci","kind":"journal","name":"JNCI: Journal of the National Cancer Institute","route":"/journals/jnci/"}]}}