{"entity":{"id":"paper-sinicrope-early-onset-crc-nejm-2022","kind":"paper","name":"Increasing incidence of early-onset colorectal cancer (review)","aka":[],"tldr":"This review explains the rise of colorectal cancer in adults under 50, what is known about its causes and distinct features, and how screening ages and clinical management have responded.","summary":"Review of the epidemiology of colorectal cancer diagnosed before age 50, including birth-cohort effects, proposed risk factors (obesity, diet, microbiome, antibiotics), clinical and molecular features (left-sided and rectal predominance, later stage at diagnosis, similar mutational profiles in sporadic cases), germline findings, and implications for screening and treatment.","asOf":"2026-09-17","links":[{"label":"N Engl J Med 2022","url":"https://doi.org/10.1056/NEJMra2200869"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/35443109/"}],"tags":[],"related":[],"cancers":["early-onset-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nejm"],"dependsOn":[],"notes":[],"journal":"New England Journal of Medicine","year":2022,"doi":"10.1056/NEJMra2200869","pmid":"35443109","authors":"Sinicrope FA.","paperType":"review","findings":[],"whatItMeans":"The early-onset colorectal cancer page's emphasis on investigating rectal bleeding at any age, universal germline testing and avoiding treatment escalation on age alone follows this framing.","caveats":["Causes remain hypotheses; no single exposure explains the trend."],"changedPractice":false},"route":"/key-papers/paper-sinicrope-early-onset-crc-nejm-2022/","neighbours":{"cancer":[{"id":"early-onset-colorectal","kind":"cancer","name":"Early-onset colorectal cancer (under 50)","route":"/cancers/early-onset-colorectal/"}],"journal":[{"id":"nejm","kind":"journal","name":"New England Journal of Medicine","route":"/journals/nejm/"}]}}