{"entity":{"id":"paper-solin-oncotype-dcis-score-jnci-2013","kind":"paper","name":"A multigene expression assay to predict local recurrence risk for ductal carcinoma in situ of the breast","aka":[],"tldr":"Validation of a 12-gene score for ductal carcinoma in situ, which separated women by their chance of the disease returning in the same breast after surgery without radiotherapy.","summary":"In 327 patients from the ECOG E5194 study treated by excision alone, the DCIS score (seven cancer-related and five reference genes, measured with the Oncotype DX assay) was associated with ipsilateral breast events; ten-year risks were 10.6, 26.7 and 25.9 per cent for low, intermediate and high scores.","asOf":"2026-11-04","links":[{"label":"Solin et al., J Natl Cancer Inst 2013","url":"https://doi.org/10.1093/jnci/djt067"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/23641039/"}],"tags":[],"related":[],"cancers":["ductal-carcinoma-in-situ"],"sections":["diagnostics"],"technologies":["gene-expression-prognostic-assays"],"targets":[],"drugs":["oncotype-dx-dcis"],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Journal of the National Cancer Institute","year":2013,"doi":"10.1093/jnci/djt067","pmid":"23641039","authors":"Solin LJ, Gray R, Baehner FL, et al.","paperType":"translational","findings":["Ten-year ipsilateral breast event risk 10.6% (low), 26.7% (intermediate), 25.9% (high)."],"whatItMeans":"A gene-activity score can tell some women with DCIS that their chance of recurrence after surgery alone is lower.","caveats":["Secondary analysis of a single-arm study."],"participants":327},"route":"/key-papers/paper-solin-oncotype-dcis-score-jnci-2013/","neighbours":{"cancer":[{"id":"ductal-carcinoma-in-situ","kind":"cancer","name":"Ductal carcinoma in situ (DCIS)","route":"/cancers/ductal-carcinoma-in-situ/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"gene-expression-prognostic-assays","kind":"technology","name":"Gene-expression prognostic assays","route":"/technologies/gene-expression-prognostic-assays/"}],"drug":[{"id":"oncotype-dx-dcis","kind":"drug","name":"Oncotype DX Breast DCIS Score","route":"/drugs/oncotype-dx-dcis/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}