{"entity":{"id":"paper-steward-thyroseq-v3-indeterminate-nodules-jama-oncol-2019","kind":"paper","name":"Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology: A Prospective Blinded Multicenter Study","aka":[],"tldr":"A prospective blinded study showing how well the ThyroSeq v3 test sorted thyroid nodules whose needle sample was uncertain.","summary":"The classifier had 94 per cent (95% CI 86 to 98) sensitivity and 82 per cent (95% CI 75 to 87) specificity, with a negative predictive value of 97 per cent.","asOf":"2026-11-04","links":[{"label":"Steward et al., JAMA Oncol 2019","url":"https://doi.org/10.1001/jamaoncol.2018.4616"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/30419129/"}],"tags":[],"related":[],"cancers":["thyroid"],"sections":["diagnostics"],"technologies":["thyroid-fna-molecular"],"targets":[],"drugs":["thyroseq"],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"JAMA Oncology","year":2019,"doi":"10.1001/jamaoncol.2018.4616","pmid":"30419129","authors":"Steward DL, Carty SE, Sippel RS, et al.","paperType":"translational","findings":["Sensitivity 94%, specificity 82%, negative predictive value 97%."],"whatItMeans":"A negative result makes cancer unlikely enough that some people can avoid diagnostic surgery.","caveats":["Predictive values depend on how common cancer is in the population tested."]},"route":"/key-papers/paper-steward-thyroseq-v3-indeterminate-nodules-jama-oncol-2019/","neighbours":{"cancer":[{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"thyroid-fna-molecular","kind":"technology","name":"Thyroid nodule FNA, Bethesda cytology & molecular classifiers","route":"/technologies/thyroid-fna-molecular/"}],"drug":[{"id":"thyroseq","kind":"drug","name":"ThyroSeq v3 Genomic Classifier","route":"/drugs/thyroseq/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}