{"entity":{"id":"paper-tan-phyllodes-consensus-histopathology-2016","kind":"paper","name":"Phyllodes tumours of the breast: a consensus review","aka":[],"tldr":"This international consensus review sets out how pathologists grade phyllodes tumours as benign, borderline or malignant and how those grades should guide surgery and follow-up.","summary":"Consensus review by an international group of breast pathologists on the diagnosis, grading criteria (stromal cellularity, atypia, mitoses, overgrowth and margins), differential diagnosis from fibroadenoma, molecular findings including MED12 mutations, and management implications for phyllodes tumours.","asOf":"2026-09-17","links":[{"label":"Histopathology 2016","url":"https://doi.org/10.1111/his.12876"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/26768026/"}],"tags":[],"related":[],"cancers":["phyllodes-tumour"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Histopathology","year":2016,"doi":"10.1111/his.12876","pmid":"26768026","authors":"Tan BY, Acs G, Apple SK, et al.","paperType":"review","findings":[],"whatItMeans":"The three-tier grading on a phyllodes pathology report and the margin recommendations for each grade follow this review and the WHO classification it informed.","caveats":["Grading remains partly subjective and inter-observer variation persists."],"changedPractice":true},"route":"/key-papers/paper-tan-phyllodes-consensus-histopathology-2016/","neighbours":{"cancer":[{"id":"phyllodes-tumour","kind":"cancer","name":"Phyllodes tumour of the breast","route":"/cancers/phyllodes-tumour/"}]}}