{"entity":{"id":"paper-tang-ivermectin-potential-anticancer-pharmacol-res-2021","kind":"paper","name":"Ivermectin, a potential anticancer drug derived from an antiparasitic drug","aka":[],"tldr":"A 2021 review of the pathways through which ivermectin killed cancer cells in the laboratory, written as a case for testing it in people.","summary":"The review, indexed as a systematic review, collects reports that ivermectin inhibits proliferation of several tumour cell types by regulating multiple signalling pathways and promotes programmed cell death, and discusses prospects for clinical use (Tang review 2021). The evidence it reviews is from cell lines and animal models (Tang review 2021).","asOf":"2026-09-24","links":[{"label":"Tang review 2021","url":"https://doi.org/10.1016/j.phrs.2020.105207"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/32971268/"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":["drug-repurposing"],"targets":[],"drugs":["ivermectin"],"companies":[],"institutions":[],"pathways":[],"terms":["preclinical","in-vitro-in-vivo"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo agent (Claude Fable 5.1)","editedOn":"2026-09-24","note":"Written from cached ClinicalTrials.gov v2, Europe PMC, DailyMed, Drugs@FDA and WHO eEML responses; no figure appears without its source link."},"journal":"Pharmacological Research","year":2021,"doi":"10.1016/j.phrs.2020.105207","pmid":"32971268","authors":"Tang M, Hu X, Wang Y, et al.","paperType":"review","findings":["Laboratory mechanisms catalogued: proliferation inhibition and programmed cell death across cancer cell lines."],"whatItMeans":"Useful as a map of the laboratory story; it contains no patient outcomes.","caveats":["Preclinical evidence only."],"changedPractice":false},"route":"/key-papers/paper-tang-ivermectin-potential-anticancer-pharmacol-res-2021/","neighbours":{"technology":[{"id":"drug-repurposing","kind":"technology","name":"Systematic drug repurposing","route":"/technologies/drug-repurposing/"}],"drug":[{"id":"ivermectin","kind":"drug","name":"Ivermectin","route":"/drugs/ivermectin/"}],"term":[{"id":"in-vitro-in-vivo","kind":"term","name":"In vitro and in vivo","route":"/terms/in-vitro-in-vivo/"},{"id":"preclinical","kind":"term","name":"Preclinical","route":"/terms/preclinical/"}]}}