{"entity":{"id":"paper-tarpswg-retroperitoneal-sarcoma-gronchi-ann-surg-2016","kind":"paper","name":"Variability in patterns of recurrence after resection of primary retroperitoneal sarcoma (TARPSWG)","aka":[],"tldr":"Pooling over a thousand patients from eight expert centres showed that recurrence after retroperitoneal sarcoma surgery depends on histology: liposarcoma recurs locally, leiomyosarcoma spreads distantly, which shapes follow-up and the case for radiotherapy or chemotherapy by subtype.","summary":"Retrospective analysis of 1,007 patients with primary retroperitoneal sarcoma treated with curative-intent surgery at eight Trans-Atlantic Retroperitoneal Sarcoma Working Group centres, describing patterns of local and distant recurrence and survival by histology.\n\nFive-year overall survival was 67 percent; well-differentiated liposarcoma recurred locally with almost no metastases, dedifferentiated liposarcoma recurred both ways, and leiomyosarcoma had a high distant recurrence rate with low local recurrence.","asOf":"2026-09-17","links":[{"label":"Ann Surg 2016","url":"https://doi.org/10.1097/SLA.0000000000001447"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/26727100/"}],"tags":[],"related":[],"cancers":["retroperitoneal-sarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Annals of Surgery","year":2016,"doi":"10.1097/SLA.0000000000001447","pmid":"26727100","authors":"Gronchi A, Strauss DC, Miceli R, et al.","paperType":"observational","findings":["Five-year overall survival 67 percent after complete resection.","Local recurrence dominant in liposarcoma; distant recurrence dominant in leiomyosarcoma."],"whatItMeans":"Histology-specific strategies, such as considering neoadjuvant chemotherapy for leiomyosarcoma and high-grade dedifferentiated liposarcoma in STRASS2, follow from these patterns.","caveats":["Retrospective data from expert centres; results may not generalise to non-specialist surgery."],"changedPractice":true,"participants":1007},"route":"/key-papers/paper-tarpswg-retroperitoneal-sarcoma-gronchi-ann-surg-2016/","neighbours":{"cancer":[{"id":"retroperitoneal-sarcoma","kind":"cancer","name":"Retroperitoneal sarcoma","route":"/cancers/retroperitoneal-sarcoma/"}]}}