{"entity":{"id":"paper-tcga-endometrial-nature-2013","kind":"paper","name":"Integrated genomic characterisation of endometrial carcinoma (The Cancer Genome Atlas)","aka":[],"tldr":"Sequencing of 373 endometrial cancers revealed four molecular groups, POLE ultramutated, microsatellite unstable, copy-number low and copy-number high, that cut across the traditional endometrioid and serous types and predict outcome.","summary":"Integrated genomic, transcriptomic and proteomic analysis of 373 endometrial carcinomas by The Cancer Genome Atlas defining four groups: POLE ultramutated (with excellent outcome), microsatellite instability hypermutated, copy-number low (endometrioid) and copy-number high (serous-like, TP53-mutated, worst outcome); about a quarter of high-grade endometrioid tumours resembled serous carcinoma molecularly.","asOf":"2026-09-17","links":[{"label":"Nature 2013","url":"https://doi.org/10.1038/nature12113"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/23636398/"}],"tags":[],"related":[],"cancers":["endometrial-pole-ultramutated","endometrial-p53-abnormal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nature"],"dependsOn":[],"notes":[],"journal":"Nature","year":2013,"doi":"10.1038/nature12113","pmid":"23636398","authors":"Cancer Genome Atlas Research Network, Kandoth C, Schultz N, et al.","paperType":"translational","findings":["Four molecular subgroups with distinct progression-free survival.","25 percent of high-grade endometrioid tumours had serous-like copy-number-high profiles."],"whatItMeans":"This is the origin of the molecular classification now used for every endometrial cancer, translated into a practical test by ProMisE.","caveats":["Research-grade sequencing; clinical surrogates were needed for routine use."],"changedPractice":true,"participants":373},"route":"/key-papers/paper-tcga-endometrial-nature-2013/","neighbours":{"cancer":[{"id":"endometrial-p53-abnormal","kind":"cancer","name":"p53-abnormal endometrial cancer, including uterine serous carcinoma","route":"/cancers/endometrial-p53-abnormal/"},{"id":"endometrial-pole-ultramutated","kind":"cancer","name":"POLE-ultramutated endometrial cancer","route":"/cancers/endometrial-pole-ultramutated/"}],"journal":[{"id":"nature","kind":"journal","name":"Nature","route":"/journals/nature/"}]}}