{"entity":{"id":"paper-tcga-ovarian-nature-2011","kind":"paper","name":"Integrated genomic analyses of ovarian carcinoma (The Cancer Genome Atlas)","aka":[],"tldr":"Sequencing nearly 500 high-grade serous ovarian cancers showed that almost all carry TP53 mutations and about half have defects in homologous recombination DNA repair, the biology that PARP inhibitors exploit.","summary":"Integrated genomic analysis by The Cancer Genome Atlas of 489 high-grade serous ovarian adenocarcinomas, finding TP53 mutations in 96 percent, germline or somatic BRCA1/2 mutations in about 20 percent, homologous recombination defects in about half, widespread copy-number changes, and four transcriptional subtypes.","asOf":"2026-09-17","links":[{"label":"Nature 2011","url":"https://doi.org/10.1038/nature10166"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/21720365/"}],"tags":[],"related":[],"cancers":["high-grade-serous-ovarian-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nature"],"dependsOn":[],"notes":[],"journal":"Nature","year":2011,"doi":"10.1038/nature10166","pmid":"21720365","authors":"Cancer Genome Atlas Research Network.","paperType":"translational","findings":["TP53 mutated in 96 percent of high-grade serous ovarian cancers.","Homologous recombination pathway defects in about 50 percent, including BRCA1/2 in about 20 percent."],"whatItMeans":"The homologous recombination deficiency concept, and the case for testing all high-grade serous cancers for BRCA and related defects, come from this dataset.","caveats":["Research-grade profiling of primary tumours; clinical homologous recombination deficiency assays came later."],"changedPractice":true,"participants":489},"route":"/key-papers/paper-tcga-ovarian-nature-2011/","neighbours":{"cancer":[{"id":"high-grade-serous-ovarian-cancer","kind":"cancer","name":"High-grade serous ovarian cancer","route":"/cancers/high-grade-serous-ovarian-cancer/"}],"journal":[{"id":"nature","kind":"journal","name":"Nature","route":"/journals/nature/"}]}}