{"entity":{"id":"paper-tonon-crtc1-maml2-nat-genet-2003","kind":"paper","name":"The t(11;19) translocation in mucoepidermoid carcinoma creates a CRTC1-MAML2 fusion","aka":[],"tldr":"This study identified the gene fusion (CRTC1-MAML2, originally called MECT1-MAML2) created by the characteristic chromosome translocation in mucoepidermoid carcinoma, giving the tumour a defining molecular marker.","summary":"Molecular characterisation of the recurrent t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma showing fusion of the CREB coactivator MECT1 (CRTC1) to the Notch coactivator MAML2, producing a fusion protein that disrupts Notch signalling and activates CREB targets.","asOf":"2026-09-17","links":[{"label":"Nat Genet 2003","url":"https://doi.org/10.1038/ng1083"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/12539049/"}],"tags":[],"related":[],"cancers":["mucoepidermoid-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nature-genetics"],"dependsOn":[],"notes":[],"journal":"Nature Genetics","year":2003,"doi":"10.1038/ng1083","pmid":"12539049","authors":"Tonon G, Modi S, Wu L, et al.","paperType":"basic","findings":["Recurrent CRTC1-MAML2 fusion in mucoepidermoid carcinoma from the t(11;19) translocation."],"whatItMeans":"CRTC1-MAML2 fusion testing supports the diagnosis of mucoepidermoid carcinoma, particularly in difficult cases, and fusion-positive tumours tend to be lower grade with a better outlook.","caveats":["Not yet a therapeutic target."],"changedPractice":true},"route":"/key-papers/paper-tonon-crtc1-maml2-nat-genet-2003/","neighbours":{"cancer":[{"id":"mucoepidermoid-carcinoma","kind":"cancer","name":"Mucoepidermoid carcinoma","route":"/cancers/mucoepidermoid-carcinoma/"}],"journal":[{"id":"nature-genetics","kind":"journal","name":"Nature Genetics","route":"/journals/nature-genetics/"}]}}