{"entity":{"id":"paper-tosoian-18-gene-urine-prostate-jama-oncol-2024","kind":"paper","name":"Development and Validation of an 18-Gene Urine Test for High-Grade Prostate Cancer","aka":[],"tldr":"The development and validation of an 18-gene urine test that outperformed the blood PSA test at finding prostate cancers worth treating.","summary":"In a validation cohort of 743, the area under the curve was 0.81 for MPS2 and 0.82 for MPS2+, against 0.60 for PSA alone and 0.77 for the Prostate Health Index, with negative predictive values of 95 to 99 per cent for grade group 2 or higher cancer.","asOf":"2026-11-04","links":[{"label":"Tosoian et al., JAMA Oncol 2024","url":"https://doi.org/10.1001/jamaoncol.2024.0455"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/38635241/"}],"tags":[],"related":[],"cancers":["prostate"],"sections":["diagnostics"],"technologies":["liquid-rna-biopsy"],"targets":[],"drugs":["myprostatescore-2"],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"JAMA Oncology","year":2024,"doi":"10.1001/jamaoncol.2024.0455","pmid":"38635241","authors":"Tosoian JJ, Zhang Y, Xiao L, et al.","paperType":"translational","findings":["Area under the curve 0.81 to 0.82 against 0.60 for PSA.","Negative predictive value 95% to 99%."],"whatItMeans":"A urine RNA panel can rule out significant prostate cancer for many men.","caveats":["Validation within a research network; MRI not used for everyone."],"participants":743},"route":"/key-papers/paper-tosoian-18-gene-urine-prostate-jama-oncol-2024/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"liquid-rna-biopsy","kind":"technology","name":"Liquid RNA biopsy (cell-free, vesicle and platelet RNA)","route":"/technologies/liquid-rna-biopsy/"},{"id":"prostate-screening-psa-mri","kind":"technology","name":"PSA and MRI-first prostate cancer screening","route":"/technologies/prostate-screening-psa-mri/"}],"drug":[{"id":"myprostatescore-2","kind":"drug","name":"MyProstateScore 2.0","route":"/drugs/myprostatescore-2/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}