{"entity":{"id":"paper-trucheck-c-etac-cancer-cytopathol-2021","kind":"paper","name":"Evaluation of circulating tumor cell clusters for pan-cancer noninvasive diagnostic triaging","aka":[],"tldr":"Datar Cancer Genetics' study of 30,060 people reported clumps of tumour-associated cells in the blood of about nine in ten people with cancer and about four in a hundred people without symptoms.","summary":"Gaya and colleagues harvested circulating ensembles of tumour-associated cells (C-ETACs) from 30,060 people: 9,416 with known cancer, 6,725 symptomatic with suspected cancer and 13,919 asymptomatic. C-ETACs were found in 91.8% of people with known cancer and in 92.6% of the 6,025 symptomatic people diagnosed with cancer; in a subset of 3,509, immunocytochemistry profiles matched histopathology in 93.1%. C-ETACs were undetectable in 95% of 700 symptomatic people with benign conditions and in 96.3% of the 13,919 asymptomatic individuals.","asOf":"2026-10-29","links":[{"label":"Cancer Cytopathology 2021","url":"https://doi.org/10.1002/cncy.22366"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/32996712/"}],"tags":[],"related":[],"cancers":[],"sections":["early-detection"],"technologies":["mced","ctc-capture"],"targets":[],"drugs":["trucheck-intelli"],"companies":["datar-cancer-genetics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Cancer Cytopathology","year":2021,"doi":"10.1002/cncy.22366","pmid":"32996712","authors":"Gaya A, Crook T, Plowman N, et al.","paperType":"observational","findings":["C-ETACs in 91.8% of 9,416 people with known cancer.","Undetectable in 96.3% of 13,919 asymptomatic people (about 3.7% positive).","Profile matched histology in 93.1% of 3,509."],"whatItMeans":"If about 3.7% of people without symptoms test positive, most positives in a screening population would not be cancer; the paper does not report how many asymptomatic positives were later diagnosed.","caveats":["Company-authored.","No stage breakdown or screening positive predictive value in the abstract."],"changedPractice":false,"participants":30060},"route":"/key-papers/paper-trucheck-c-etac-cancer-cytopathol-2021/","neighbours":{"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"}],"technology":[{"id":"ctc-capture","kind":"technology","name":"Circulating tumour cell capture","route":"/technologies/ctc-capture/"},{"id":"mced","kind":"technology","name":"Multi-cancer early detection (MCED)","route":"/technologies/mced/"}],"drug":[{"id":"trucheck-intelli","kind":"drug","name":"Trucheck Intelli","route":"/drugs/trucheck-intelli/"}],"company":[{"id":"datar-cancer-genetics","kind":"company","name":"Datar Cancer Genetics","route":"/companies/datar-cancer-genetics/"}]}}