{"entity":{"id":"paper-uspstf-crc-screening-45-jama-2021","kind":"paper","name":"US Preventive Services Task Force recommendation: colorectal cancer screening from age 45","aka":[],"tldr":"In 2021 the US Preventive Services Task Force lowered the recommended age to start colorectal cancer screening from 50 to 45 for average-risk adults, in response to rising rates in younger people.","summary":"Recommendation statement based on systematic review and modelling concluding with moderate certainty that screening adults aged 45 to 49 has moderate net benefit (B recommendation), continuing the A recommendation for ages 50 to 75, with a range of acceptable tests including colonoscopy, faecal immunochemical testing, stool DNA testing and CT colonography.","asOf":"2026-09-17","links":[{"label":"JAMA 2021","url":"https://doi.org/10.1001/jama.2021.6238"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/34003218/"}],"tags":[],"related":[],"cancers":["early-onset-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["jama"],"dependsOn":[],"notes":[],"journal":"JAMA","year":2021,"doi":"10.1001/jama.2021.6238","pmid":"34003218","authors":"US Preventive Services Task Force, Davidson KW, Barry MJ, et al.","paperType":"guideline","findings":[],"whatItMeans":"Screening from 45 is now standard in the United States and has been adopted or debated elsewhere; it is the main policy response to early-onset colorectal cancer.","caveats":["Modelling-based; uptake in the 45 to 49 group has been slow.","Benefit for those under 45 remains unaddressed."],"changedPractice":true},"route":"/key-papers/paper-uspstf-crc-screening-45-jama-2021/","neighbours":{"cancer":[{"id":"early-onset-colorectal","kind":"cancer","name":"Early-onset colorectal cancer (under 50)","route":"/cancers/early-onset-colorectal/"}],"journal":[{"id":"jama","kind":"journal","name":"JAMA","route":"/journals/jama/"}]}}