{"entity":{"id":"paper-van-neste-urinary-biomarker-prostate-eur-urol-2016","kind":"paper","name":"Detection of High-grade Prostate Cancer Using a Urinary Molecular Biomarker-Based Risk Score","aka":[],"tldr":"The validation of a urine test reading two genes, combined with clinical factors, to detect high-grade prostate cancer.","summary":"The multimodal approach reached an overall area under the curve of 0.90 (95% CI 0.85 to 0.95) in the validation cohort.","asOf":"2026-11-04","links":[{"label":"Van Neste et al., Eur Urol 2016","url":"https://doi.org/10.1016/j.eururo.2016.04.012"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/27108162/"}],"tags":[],"related":[],"cancers":["prostate"],"sections":["diagnostics"],"technologies":["liquid-rna-biopsy"],"targets":[],"drugs":["selectmdx"],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"European Urology","year":2016,"doi":"10.1016/j.eururo.2016.04.012","pmid":"27108162","authors":"Van Neste L, Hendriks RJ, Dijkstra S, et al.","paperType":"translational","findings":["Area under the curve 0.90 in validation."],"whatItMeans":"Urine mRNA plus clinical factors separates high-grade from low-grade or no cancer.","caveats":["Urine taken after a rectal examination."]},"route":"/key-papers/paper-van-neste-urinary-biomarker-prostate-eur-urol-2016/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"liquid-rna-biopsy","kind":"technology","name":"Liquid RNA biopsy (cell-free, vesicle and platelet RNA)","route":"/technologies/liquid-rna-biopsy/"}],"drug":[{"id":"selectmdx","kind":"drug","name":"SelectMDx","route":"/drugs/selectmdx/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}