{"entity":{"id":"paper-wang-urinary-exosome-small-rna-prostate-j-urol-2020","kind":"paper","name":"Expression of Small Noncoding RNAs in Urinary Exosomes Classifies Prostate Cancer into Indolent and Aggressive Disease","aka":[],"tldr":"The first report of a urine test reading small RNAs from vesicles to detect prostate cancer and judge its grade.","summary":"Small non-coding RNAs from urinary exosomes of 235 participants were read on microarrays to build classifiers, which were then validated in a case-control sample of 1,436 subjects with 94 per cent sensitivity and 92 per cent specificity.","asOf":"2026-11-04","links":[{"label":"Wang et al., J Urol 2020","url":"https://doi.org/10.1097/ju.0000000000001020"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/32191585/"}],"tags":[],"related":[],"cancers":["prostate"],"sections":["diagnostics"],"technologies":["liquid-rna-biopsy"],"targets":[],"drugs":["mir-sentinel"],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Journal of Urology","year":2020,"doi":"10.1097/ju.0000000000001020","pmid":"32191585","authors":"Wang WW, Sorokin I, Aleksic I, et al.","paperType":"translational","findings":["Validation sensitivity 94%, specificity 92% (case-control)."],"whatItMeans":"Promising, but case-control designs overstate accuracy compared with testing the people who would actually use it.","caveats":["Case-control design."]},"route":"/key-papers/paper-wang-urinary-exosome-small-rna-prostate-j-urol-2020/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"liquid-rna-biopsy","kind":"technology","name":"Liquid RNA biopsy (cell-free, vesicle and platelet RNA)","route":"/technologies/liquid-rna-biopsy/"}],"drug":[{"id":"mir-sentinel","kind":"drug","name":"miR Sentinel","route":"/drugs/mir-sentinel/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}