{"entity":{"id":"paper-who-2019-digestive-system-tumours-nagtegaal-histopathology-2020","kind":"paper","name":"The 2019 WHO classification of tumours of the digestive system","aka":[],"tldr":"The current WHO rulebook for cancers of the gut, which among other changes renamed goblet cell carcinoid as goblet cell adenocarcinoma, adopted the LAMN terminology for appendiceal tumours and re-graded neuroendocrine neoplasms.","summary":"Overview by the WHO Classification of Tumours Editorial Board of the fifth-edition digestive system volume, summarising changes across oesophagus, stomach, small bowel, appendix, colorectum, liver, biliary tract and pancreas.\n\nFor the appendix it adopts low-grade and high-grade appendiceal mucinous neoplasm and reclassifies goblet cell carcinoid as goblet cell adenocarcinoma with a three-tier grade; it also separates neuroendocrine tumours from neuroendocrine carcinomas and introduces molecular subtypes across sites.","asOf":"2026-09-18","links":[{"label":"Histopathology 2020","url":"https://doi.org/10.1111/his.13975"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/31433515/"}],"tags":[],"related":[],"cancers":["low-grade-appendiceal-mucinous-neoplasm","appendiceal-adenocarcinoma","goblet-cell-adenocarcinoma","localised-small-bowel-adenocarcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Histopathology","year":2020,"doi":"10.1111/his.13975","pmid":"31433515","authors":"Nagtegaal ID, Odze RD, Klimstra D, et al.","paperType":"review","findings":[],"whatItMeans":"The names on an appendix or small bowel pathology report, and hence which OnCo subtype page applies, follow this classification.","caveats":["The summary paper describes the changes; the full volume holds the diagnostic criteria.","Some renamings (goblet cell adenocarcinoma) are still working through registries and older literature."],"changedPractice":true},"route":"/key-papers/paper-who-2019-digestive-system-tumours-nagtegaal-histopathology-2020/","neighbours":{"cancer":[{"id":"appendiceal-adenocarcinoma","kind":"cancer","name":"Appendiceal adenocarcinoma (mucinous and non-mucinous, including signet ring cell)","route":"/cancers/appendiceal-adenocarcinoma/"},{"id":"goblet-cell-adenocarcinoma","kind":"cancer","name":"Goblet cell adenocarcinoma of the appendix","route":"/cancers/goblet-cell-adenocarcinoma/"},{"id":"localised-small-bowel-adenocarcinoma","kind":"cancer","name":"Localised small bowel adenocarcinoma (stage I to III, resected)","route":"/cancers/localised-small-bowel-adenocarcinoma/"},{"id":"low-grade-appendiceal-mucinous-neoplasm","kind":"cancer","name":"Low-grade appendiceal mucinous neoplasm and pseudomyxoma peritonei","route":"/cancers/low-grade-appendiceal-mucinous-neoplasm/"}]}}