{"entity":{"id":"paper-wiegand-arid1a-clear-cell-nejm-2010","kind":"paper","name":"ARID1A mutations in endometriosis-associated ovarian carcinomas","aka":[],"tldr":"This study found that about half of ovarian clear cell carcinomas and a third of endometrioid carcinomas carry inactivating mutations in ARID1A, a chromatin remodelling gene, linking these endometriosis-associated cancers to a common driver.","summary":"Sequencing study identifying truncating ARID1A mutations in 46 percent of ovarian clear cell carcinomas and 30 percent of endometrioid carcinomas but not in high-grade serous carcinoma, with loss of the BAF250a protein in mutated tumours and evidence of the mutation in adjacent endometriosis.","asOf":"2026-09-17","links":[{"label":"N Engl J Med 2010","url":"https://doi.org/10.1056/NEJMoa1008433"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/20942669/"}],"tags":[],"related":[],"cancers":["clear-cell-ovarian-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nejm"],"dependsOn":[],"notes":[],"journal":"New England Journal of Medicine","year":2010,"doi":"10.1056/NEJMoa1008433","pmid":"20942669","authors":"Wiegand KC, Shah SP, Al-Agha OM, et al.","paperType":"translational","findings":["ARID1A mutations in 46 percent of clear cell and 30 percent of endometrioid ovarian carcinomas.","No ARID1A mutations in high-grade serous carcinoma."],"whatItMeans":"ARID1A loss defines the biology of clear cell ovarian cancer and is the target of current trials of synthetic-lethal drugs such as ATR and EZH2 inhibitors.","caveats":["No ARID1A-directed therapy has yet been approved."],"changedPractice":true},"route":"/key-papers/paper-wiegand-arid1a-clear-cell-nejm-2010/","neighbours":{"cancer":[{"id":"clear-cell-ovarian-cancer","kind":"cancer","name":"Clear cell ovarian cancer","route":"/cancers/clear-cell-ovarian-cancer/"}],"journal":[{"id":"nejm","kind":"journal","name":"New England Journal of Medicine","route":"/journals/nejm/"}]}}