{"entity":{"id":"paper-wysong-40-gene-cutaneous-scc-j-am-acad-dermatol-2021","kind":"paper","name":"Validation of a 40-gene expression profile test to predict metastatic risk in localized high-risk cutaneous squamous cell carcinoma","aka":[],"tldr":"The validation of a 40-gene test in high-risk squamous cell skin cancer, which separated three groups by their chance of spread.","summary":"Three-year metastasis-free survival rates were 91.4, 80.6 and 44.0 per cent for classes 1, 2A and 2B.","asOf":"2026-11-04","links":[{"label":"Wysong et al., J Am Acad Dermatol 2021","url":"https://doi.org/10.1016/j.jaad.2020.04.088"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/32344066/"}],"tags":[],"related":[],"cancers":["cutaneous-scc"],"sections":["diagnostics"],"technologies":["gene-expression-prognostic-assays"],"targets":[],"drugs":["decisiondx-scc"],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"Journal of the American Academy of Dermatology","year":2021,"doi":"10.1016/j.jaad.2020.04.088","pmid":"32344066","authors":"Wysong A, Newman JG, Covington KR, et al.","paperType":"translational","findings":["Three-year metastasis-free survival 91.4%, 80.6% and 44.0% by class."],"whatItMeans":"A risk class exists; whether acting on it improves outcomes is not shown, and Medicare does not cover it.","caveats":["Retrospective; industry-sponsored."]},"route":"/key-papers/paper-wysong-40-gene-cutaneous-scc-j-am-acad-dermatol-2021/","neighbours":{"cancer":[{"id":"cutaneous-scc","kind":"cancer","name":"Cutaneous squamous cell carcinoma","route":"/cancers/cutaneous-scc/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"gene-expression-prognostic-assays","kind":"technology","name":"Gene-expression prognostic assays","route":"/technologies/gene-expression-prognostic-assays/"}],"drug":[{"id":"decisiondx-scc","kind":"drug","name":"DecisionDx-SCC","route":"/drugs/decisiondx-scc/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}]}}