{"entity":{"id":"paper-yan-peritoneal-mesothelioma-crs-hipec-jco-2009","kind":"paper","name":"Cytoreductive surgery and HIPEC for malignant peritoneal mesothelioma: multi-institutional registry","aka":[],"tldr":"Pooling eight centres, this registry showed that removing all visible peritoneal mesothelioma and washing the abdomen with heated chemotherapy gave a median survival of over four years, transforming the outlook for selected patients.","summary":"Retrospective multi-institutional registry of 405 patients with diffuse malignant peritoneal mesothelioma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy at eight specialised centres.\n\nMedian overall survival was 53 months with three- and five-year survival of 60 and 47 percent; epithelioid histology, absence of nodal metastases, completeness of cytoreduction and use of HIPEC were independently associated with survival, while perioperative mortality was 2 percent.","asOf":"2026-09-17","links":[{"label":"J Clin Oncol 2009","url":"https://doi.org/10.1200/JCO.2009.23.9640"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/19917862/"}],"tags":[],"related":[],"cancers":["peritoneal-mesothelioma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["jco"],"dependsOn":[],"notes":[],"journal":"Journal of Clinical Oncology","year":2009,"doi":"10.1200/JCO.2009.23.9640","pmid":"19917862","authors":"Yan TD, Deraco M, Baratti D, et al.","paperType":"observational","findings":["Median overall survival 53 months; five-year survival 47 percent.","Completeness of cytoreduction and epithelioid subtype were the strongest prognostic factors."],"whatItMeans":"Cytoreductive surgery with HIPEC in an experienced centre is the standard for fit patients with resectable epithelioid peritoneal mesothelioma, a disease that had a median survival of about a year on chemotherapy alone.","caveats":["Retrospective registry with selection of fit patients with resectable disease.","No randomised comparison with systemic therapy exists."],"changedPractice":true,"participants":405},"route":"/key-papers/paper-yan-peritoneal-mesothelioma-crs-hipec-jco-2009/","neighbours":{"cancer":[{"id":"peritoneal-mesothelioma","kind":"cancer","name":"Peritoneal mesothelioma","route":"/cancers/peritoneal-mesothelioma/"}],"journal":[{"id":"jco","kind":"journal","name":"Journal of Clinical Oncology","route":"/journals/jco/"}]}}