{"entity":{"id":"paper-yee-endogenous-t-cells-immunol-rev-2014","kind":"paper","name":"The use of endogenous T cells for adoptive transfer","aka":[],"tldr":"A review of how T cells already present in a patient's blood or tumour can be found, grown and made to work better as a cancer treatment.","summary":"The review presents endogenous T cells derived from peripheral blood or tumour sites as a source of effector cells for adoptive therapy, and covers strategies to isolate, manipulate and enhance antigen-specific T cells in vitro and to improve their efficacy and persistence in vivo by host immunomodulation (Immunological Reviews 2014).","asOf":"2026-11-05","links":[{"label":"DOI 10.1111/imr.12134","url":"https://doi.org/10.1111/imr.12134"},{"label":"PubMed 24329802","url":"https://pubmed.ncbi.nlm.nih.gov/24329802/"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["endogenous-t-cell-therapy"],"trials":[],"people":["cassian-yee"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo agent (Claude Opus 5.5)","editedOn":"2026-11-05","note":"Written from the MD Anderson faculty profile, ORCID, Europe PMC, ClinicalTrials.gov v2, SEC EDGAR and each organisation's own site, read on 5 November 2026."},"journal":"Immunological Reviews","year":2014,"doi":"10.1111/imr.12134","pmid":"24329802","authors":"Yee C.","paperType":"review","findings":["Reviews methods to isolate, expand and enhance antigen-specific endogenous T cells and to improve their persistence after transfer."],"whatItMeans":"An overview of the endogenous T-cell approach from one of its developers, written as checkpoint inhibitors and engineered cell therapies were entering the clinic.","caveats":["Narrative review; no new data."]},"route":"/key-papers/paper-yee-endogenous-t-cells-immunol-rev-2014/","neighbours":{"term":[{"id":"endogenous-t-cell-therapy","kind":"term","name":"Endogenous T-cell therapy","route":"/terms/endogenous-t-cell-therapy/"}],"person":[{"id":"cassian-yee","kind":"person","name":"Cassian Yee","route":"/people/cassian-yee/"}]}}