{"entity":{"id":"paper-yen-ev-protein-mrna-ovarian-ebiomedicine-2025","kind":"paper","name":"Tumour extracellular vesicle surface Protein-mRNA integration assay for early detection of epithelial ovarian cancer","aka":[],"tldr":"An ovarian cancer study that captured tumour vesicles from blood by surface proteins, including TROP2, and then read RNA inside them.","summary":"Three ovarian cancer vesicle surface markers (FRalpha, MSLN and TROP2) were used; the integrated score had an area under the curve of 0.99 in training and 0.93 (95% CI 0.88 to 0.97) in validation, and 0.93 for stage I and II.","asOf":"2026-11-04","links":[{"label":"Yen et al., eBioMedicine 2025","url":"https://doi.org/10.1016/j.ebiom.2025.105884"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/40803203/"}],"tags":[],"related":[],"cancers":["ovarian"],"sections":["early-detection"],"technologies":["liquid-rna-biopsy"],"targets":["trop2"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["biomarker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"journal":"eBioMedicine","year":2025,"doi":"10.1016/j.ebiom.2025.105884","pmid":"40803203","authors":"Yen YT, Zhao C, Gao T, et al.","paperType":"translational","findings":["Validation area under the curve 0.93."],"whatItMeans":"Capturing tumour vesicles by a surface marker before reading their RNA is feasible; it was tested for detection, not residual disease.","caveats":["Case-control; reference transcripts rather than target expression."],"participants":236},"route":"/key-papers/paper-yen-ev-protein-mrna-ovarian-ebiomedicine-2025/","neighbours":{"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"}],"technology":[{"id":"liquid-rna-biopsy","kind":"technology","name":"Liquid RNA biopsy (cell-free, vesicle and platelet RNA)","route":"/technologies/liquid-rna-biopsy/"}],"target":[{"id":"trop2","kind":"target","name":"TROP2","route":"/targets/trop2/"}],"term":[{"id":"biomarker","kind":"term","name":"Biomarker","route":"/terms/biomarker/"}],"idea":[{"id":"idea-stack-ctdna-and-tumour-rna-residual-disease","kind":"idea","name":"Read tumour RNA and tumour DNA from the same blood draw to find and type residual cancer","route":"/ideas/idea-stack-ctdna-and-tumour-rna-residual-disease/"}]}}