{"entity":{"id":"papss1","kind":"target","name":"PAPSS1","aka":["3'-phosphoadenosine 5'-phosphosulfate synthase 1","Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1","ATPSK1","PAPSS"],"tldr":"PAPSS1 (Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.81, affected pathway 0.89, genetic association 0.39).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8603","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8603"},{"label":"UniProt O43252","url":"https://www.uniprot.org/uniprotkb/O43252/entry"},{"label":"NCBI Gene 9061","url":"https://www.ncbi.nlm.nih.gov/gene/9061"},{"label":"Ensembl ENSG00000138801","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138801"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PAPSS1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:8603","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8603","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O43252","url":"https://www.uniprot.org/uniprotkb/O43252/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000138801","url":"https://platform.opentargets.org/target/ENSG00000138801/associations","note":"association with cancer (MONDO_0004992) 0.63;  (GraphQL API, CC0)"}],"hgnc":"HGNC:8603","ensembl":"ENSG00000138801","uniprot":"O43252","entrez":"9061","biology":"Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells. Locus 4q25 (HGNC).","whereFound":[],"targetClass":"kinase","prevalence":[]},"route":"/targets/papss1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}