{"entity":{"id":"parp2","kind":"target","name":"PARP2","aka":["poly(ADP-ribose) polymerase 2","Poly [ADP-ribose] polymerase 2","ARTD2","ADPRTL2"],"tldr":"PARP2 (Poly [ADP-ribose] polymerase 2) is an enzyme. The public catalogues list it as a drug target and a DNA repair gene, and an approved or late-stage drug is recorded against it. Tied to Ovarian cancer, Breast cancer and Prostate cancer.","summary":"Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.89, animal model 0.32, genetic association 0.00, clinical 0.99).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:272","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:272"},{"label":"UniProt Q9UGN5","url":"https://www.uniprot.org/uniprotkb/Q9UGN5/entry"},{"label":"NCBI Gene 10038","url":"https://www.ncbi.nlm.nih.gov/gene/10038"},{"label":"Ensembl ENSG00000129484","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000129484"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["ovarian","breast-cancer","prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.99; UniProt keyword \"DNA repair\". Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PARP2","role":["drug-target","dna-repair"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:272","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:272","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UGN5","url":"https://www.uniprot.org/uniprotkb/Q9UGN5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000129484","url":"https://platform.opentargets.org/target/ENSG00000129484/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: prostate cancer 0.55, ovarian cancer 0.60, breast cancer 0.57 (GraphQL API, CC0)"}],"hgnc":"HGNC:272","ensembl":"ENSG00000129484","uniprot":"Q9UGN5","entrez":"10038","biology":"Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1. Following interaction with HPF1, catalyses serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP2 active site. PARP2 initiates the repair of double-strand DNA breaks: recognises and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. Location: Nucleus; Chromosome (UniProt). Locus 14q11.2 (HGNC).","whereFound":["Ovarian cancer: Open Targets association 0.60 with ovarian cancer (MONDO_0008170)","Breast cancer: Open Targets association 0.57 with breast cancer (MONDO_0007254)","Prostate cancer: Open Targets association 0.55 with prostate cancer (MONDO_0008315)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/parp2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}