{"entity":{"id":"parp3","kind":"target","name":"PARP3","aka":["poly(ADP-ribose) polymerase family member 3","Protein mono-ADP-ribosyltransferase PARP3","ADPRT3","IRT1","hPARP-3","pADPRT-3","ARTD3","ADPRTL3"],"tldr":"PARP3 (Protein mono-ADP-ribosyltransferase PARP3) is an enzyme. The public catalogues list it as a drug target and a DNA repair gene, and an approved or late-stage drug is recorded against it. Tied to Ovarian cancer and Prostate cancer.","summary":"Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.00, clinical 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:273","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:273"},{"label":"UniProt Q9Y6F1","url":"https://www.uniprot.org/uniprotkb/Q9Y6F1/entry"},{"label":"NCBI Gene 10039","url":"https://www.ncbi.nlm.nih.gov/gene/10039"},{"label":"Ensembl ENSG00000041880","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000041880"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["ovarian","prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.98; UniProt keyword \"DNA repair\". Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PARP3","role":["drug-target","dna-repair"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:273","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:273","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y6F1","url":"https://www.uniprot.org/uniprotkb/Q9Y6F1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000041880","url":"https://platform.opentargets.org/target/ENSG00000041880/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: prostate cancer 0.51, ovarian cancer 0.59 (GraphQL API, CC0)"}],"hgnc":"HGNC:273","ensembl":"ENSG00000041880","uniprot":"Q9Y6F1","entrez":"10039","biology":"Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signalling pathway leading to the reparation of DNA strand breaks. Involved in single-strand break repair by catalysing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA. Location: Nucleus; Chromosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole (UniProt). Locus 3p21.2 (HGNC).","whereFound":["Ovarian cancer: Open Targets association 0.59 with ovarian cancer (MONDO_0008170)","Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/parp3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}