{"entity":{"id":"parp4","kind":"target","name":"PARP4","aka":["poly(ADP-ribose) polymerase family member 4","Protein mono-ADP-ribosyltransferase PARP4","VAULT3","p193","VPARP","VWA5C","ARTD4","ADPRTL1"],"tldr":"PARP4 (Protein mono-ADP-ribosyltransferase PARP4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Multiple myeloma and Non-small-cell lung cancer.","summary":"Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction.\n\nIntOGen calls it a driver in 3 cohorts (3 activating, 0 loss-of-function), covering Colorectal Adenocarcinoma, Lung Adenocarcinoma, Plasma Cell Myeloma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:271","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:271"},{"label":"UniProt Q9UKK3","url":"https://www.uniprot.org/uniprotkb/Q9UKK3/entry"},{"label":"NCBI Gene 143","url":"https://www.ncbi.nlm.nih.gov/gene/143"},{"label":"Ensembl ENSG00000102699","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000102699"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["colorectal","multiple-myeloma","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PARP4","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:271","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:271","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UKK3","url":"https://www.uniprot.org/uniprotkb/Q9UKK3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen PARP4","url":"https://www.intogen.org/search?gene=PARP4","note":"driver in 3 cohorts (Act 3, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:271","ensembl":"ENSG00000102699","uniprot":"Q9UKK3","entrez":"143","biology":"Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction. Location: Cytoplasm; Nucleus; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 13q12.12 (HGNC).","whereFound":["Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)","Multiple myeloma: IntOGen driver in 1 cohort (PCM)","Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/parp4/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}