{"entity":{"id":"partiqol","kind":"trial","name":"PARTIQoL","aka":[],"tldr":"A randomised trial of protons versus IMRT for localised prostate cancer, built to see whether protons cause less bowel and bladder harm at the same cancer control.","summary":"PARTIQoL (NCT01617161) randomises men with low- or intermediate-risk localised prostate cancer to proton beam therapy or intensity-modulated photon radiotherapy, with bowel quality of life among the leading endpoints. It is one of the few adult proton-versus-photon trials that can test whether a distal LET and RBE difference near rectum and bladder is clinically real. Accrual has been slow in a field where patients can obtain protons off-trial. ClinicalTrials.gov listed the study as active, not recruiting, with primary completion in December 2025; the primary readout is not yet in the corpus.","status":"active","asOf":"2026-09-17","links":[{"label":"ClinicalTrials.gov NCT01617161","url":"https://clinicaltrials.gov/study/NCT01617161"}],"tags":["radiation-wave5"],"related":[],"cancers":["prostate"],"sections":[],"technologies":["proton-therapy","imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":["mgh"],"pathways":[],"terms":["relative-biological-effectiveness","linear-energy-transfer","alpha-beta-ratio","bragg-peak"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT01617161","phase":"3","setting":"Low- and intermediate-risk localised prostate cancer: proton beam therapy versus intensity-modulated photon radiotherapy","sponsor":"Massachusetts General Hospital","outcomes":[]},"route":"/trials/partiqol/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"},{"id":"proton-therapy","kind":"technology","name":"Proton therapy","route":"/technologies/proton-therapy/"}],"institution":[{"id":"mgh","kind":"institution","name":"Massachusetts General Hospital Cancer Center","route":"/institutions/mgh/"}],"term":[{"id":"alpha-beta-ratio","kind":"term","name":"Alpha/beta ratio","route":"/terms/alpha-beta-ratio/"},{"id":"bragg-peak","kind":"term","name":"Bragg peak","route":"/terms/bragg-peak/"},{"id":"linear-energy-transfer","kind":"term","name":"Linear energy transfer (LET)","route":"/terms/linear-energy-transfer/"},{"id":"relative-biological-effectiveness","kind":"term","name":"Relative biological effectiveness (RBE)","route":"/terms/relative-biological-effectiveness/"}],"pairing":[{"id":"proton-vs-imrt","kind":"pairing","name":"Caution: proton therapy vs IMRT","route":"/pairings/proton-vs-imrt/"}],"idea":[{"id":"idea-fund-proton-coverage-with-evidence","kind":"idea","name":"Pooled coverage-with-evidence for proton therapy across all centres","route":"/ideas/idea-fund-proton-coverage-with-evidence/"},{"id":"idea-bio2-let-rbe-ab-selects-protons","kind":"idea","name":"Use LET, RBE and alpha/beta to decide when protons beat IMRT","route":"/ideas/idea-bio2-let-rbe-ab-selects-protons/"}]}}