{"entity":{"id":"patz1","kind":"target","name":"PATZ1","aka":["POZ/BTB and AT hook containing zinc finger 1","POZ-, AT hook-, and zinc finger-containing protein 1","dJ400N23","ZBTB19","ZNF278"],"tldr":"PATZ1 (POZ-, AT hook-, and zinc finger-containing protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer and Colorectal cancer.","summary":"Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis. Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.96).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13071","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13071"},{"label":"UniProt Q9HBE1","url":"https://www.uniprot.org/uniprotkb/Q9HBE1/entry"},{"label":"NCBI Gene 23598","url":"https://www.ncbi.nlm.nih.gov/gene/23598"},{"label":"Ensembl ENSG00000100105","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100105"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["skin-cancer","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PATZ1","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:13071","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13071","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9HBE1","url":"https://www.uniprot.org/uniprotkb/Q9HBE1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000100105","url":"https://platform.opentargets.org/target/ENSG00000100105/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: colorectal cancer 0.50, skin cancer 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:13071","ensembl":"ENSG00000100105","uniprot":"Q9HBE1","entrez":"23598","biology":"Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis. Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53. Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions. Location: Nucleus (UniProt). Locus 22q12.2 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)","Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/patz1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}