{"entity":{"id":"pax7","kind":"target","name":"PAX7","aka":["paired box 7","Paired box protein Pax-7","Hup1"],"tldr":"PAX7 (Paired box protein Pax-7) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Rhabdomyosarcoma.","summary":"Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.\n\nOpen Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.93, genetic association 0.43, somatic mutation 0.97, animal model 0.56).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8621","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8621"},{"label":"UniProt P23759","url":"https://www.uniprot.org/uniprotkb/P23759/entry"},{"label":"NCBI Gene 5081","url":"https://www.ncbi.nlm.nih.gov/gene/5081"},{"label":"Ensembl ENSG00000009709","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000009709"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["sarcoma","rhabdomyosarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PAX7","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:8621","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8621","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P23759","url":"https://www.uniprot.org/uniprotkb/P23759/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000009709","url":"https://platform.opentargets.org/target/ENSG00000009709/associations","note":"association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: sarcoma 0.71, rhabdomyosarcoma 0.68 (GraphQL API, CC0)"}],"hgnc":"HGNC:8621","ensembl":"ENSG00000009709","uniprot":"P23759","entrez":"5081","biology":"Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration. Location: Nucleus (UniProt). Locus 1p36.13 (HGNC).","whereFound":["Sarcomas: Open Targets association 0.71 with sarcoma (MONDO_0005089)","Rhabdomyosarcoma: Open Targets association 0.68 with rhabdomyosarcoma (MONDO_0005212)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/pax7/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"rhabdomyosarcoma","kind":"cancer","name":"Rhabdomyosarcoma","route":"/cancers/rhabdomyosarcoma/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}