{"entity":{"id":"pax9","kind":"target","name":"PAX9","aka":["paired box 9","Paired box protein Pax-9"],"tldr":"PAX9 (Paired box protein Pax-9) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.85, animal model 0.48, genetic association 0.65).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8623","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8623"},{"label":"UniProt P55771","url":"https://www.uniprot.org/uniprotkb/P55771/entry"},{"label":"NCBI Gene 5083","url":"https://www.ncbi.nlm.nih.gov/gene/5083"},{"label":"Ensembl ENSG00000198807","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198807"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PAX9","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:8623","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8623","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P55771","url":"https://www.uniprot.org/uniprotkb/P55771/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000198807","url":"https://platform.opentargets.org/target/ENSG00000198807/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"hgnc":"HGNC:8623","ensembl":"ENSG00000198807","uniprot":"P55771","entrez":"5083","biology":"Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. Location: Nucleus (UniProt). Locus 14q13.3 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/pax9/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}