{"entity":{"id":"pbk","kind":"target","name":"PBK","aka":["PDZ binding kinase","Lymphokine-activated killer T-cell-originated protein kinase","FLJ14385","Nori-3","CT84"],"tldr":"PBK (Lymphokine-activated killer T-cell-originated protein kinase) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Non-small-cell lung cancer.","summary":"Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Gefitinib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18282","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18282"},{"label":"UniProt Q96KB5","url":"https://www.uniprot.org/uniprotkb/Q96KB5/entry"},{"label":"NCBI Gene 55872","url":"https://www.ncbi.nlm.nih.gov/gene/55872"},{"label":"Ensembl ENSG00000168078","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168078"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["gastric","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PBK","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:18282","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18282","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96KB5","url":"https://www.uniprot.org/uniprotkb/Q96KB5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PBK","url":"https://civicdb.org/features/13276","note":"2 evidence items, 0 assertions, 2 variants; diseases: Lung Non-small Cell Carcinoma, Gastric Adenocarcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:18282","ensembl":"ENSG00000168078","uniprot":"Q96KB5","entrez":"55872","biology":"Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilisation and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Locus 8p21.1 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: CIViC evidence names this disease","Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"kinase","prevalence":[]},"route":"/targets/pbk/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}