{"entity":{"id":"pcbp1","kind":"target","name":"PCBP1","aka":["poly(rC) binding protein 1","Poly(rC)-binding protein 1","HNRPE1","hnRNP-E1","HNRPX","hnRNP-X"],"tldr":"PCBP1 (Poly(rC)-binding protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Non-Hodgkin lymphoma, Renal cell carcinoma and 2 more.","summary":"Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.21, somatic mutation 0.77). IntOGen calls it a driver in 9 cohorts (5 activating, 4 loss-of-function), covering Burkitt Lymphoma, Colon Adenocarcinoma, Colorectal Adenocarcinoma, Malignant Lymphoma, Papillary Renal Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8647","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8647"},{"label":"UniProt Q15365","url":"https://www.uniprot.org/uniprotkb/Q15365/entry"},{"label":"NCBI Gene 5093","url":"https://www.ncbi.nlm.nih.gov/gene/5093"},{"label":"Ensembl ENSG00000169564","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000169564"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["colorectal","non-hodgkin-lymphoma","rcc","burkitt-lymphoma","papillary-rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 5 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PCBP1","role":["oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:8647","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8647","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q15365","url":"https://www.uniprot.org/uniprotkb/Q15365/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PCBP1","url":"https://civicdb.org/features/4123","note":"1 evidence items, 0 assertions, 1 variants; diseases: Burkitt Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000169564","url":"https://platform.opentargets.org/target/ENSG00000169564/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: colorectal cancer 0.58 (GraphQL API, CC0)"},{"label":"IntOGen PCBP1","url":"https://www.intogen.org/search?gene=PCBP1","note":"driver in 9 cohorts (Act 5, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:8647","ensembl":"ENSG00000169564","uniprot":"Q15365","entrez":"5093","biology":"Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing. Location: Nucleus; Cytoplasm (UniProt). Locus 2p13.3 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.58 with colorectal cancer (MONDO_0005575); IntOGen driver in 5 cohorts (COAD, COADREAD)","Non-Hodgkin lymphoma: IntOGen driver in 1 cohort (MLYM)","Renal cell carcinoma: IntOGen driver in 1 cohort (PRCC)","Burkitt lymphoma: CIViC evidence names this disease; IntOGen driver in 2 cohorts (BL)","Papillary renal cell carcinoma: IntOGen driver in 1 cohort (PRCC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/pcbp1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"burkitt-lymphoma","kind":"cancer","name":"Burkitt lymphoma","route":"/cancers/burkitt-lymphoma/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"papillary-rcc","kind":"cancer","name":"Papillary renal cell carcinoma","route":"/cancers/papillary-rcc/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}