{"entity":{"id":"pcm1","kind":"target","name":"PCM1","aka":["pericentriolar material 1","Pericentriolar material 1 protein","PTC4"],"tldr":"PCM1 (Pericentriolar material 1 protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.","summary":"Required for centrosome assembly and function. Essential for the correct localisation of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.46, somatic mutation 0.74). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Glioblastoma Multiforme.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8727","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8727"},{"label":"UniProt Q15154","url":"https://www.uniprot.org/uniprotkb/Q15154/entry"},{"label":"NCBI Gene 5108","url":"https://www.ncbi.nlm.nih.gov/gene/5108"},{"label":"Ensembl ENSG00000078674","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000078674"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["glioblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PCM1","role":["tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:8727","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8727","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q15154","url":"https://www.uniprot.org/uniprotkb/Q15154/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000078674","url":"https://platform.opentargets.org/target/ENSG00000078674/associations","note":"association with cancer (MONDO_0004992) 0.64;  (GraphQL API, CC0)"},{"label":"IntOGen PCM1","url":"https://www.intogen.org/search?gene=PCM1","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:8727","ensembl":"ENSG00000078674","uniprot":"Q15154","entrez":"5108","biology":"Required for centrosome assembly and function. Essential for the correct localisation of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites. Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites. Location: Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasmic granule; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite (UniProt). Locus 8p22 (HGNC).","whereFound":["Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/pcm1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}]}}