{"entity":{"id":"pcnx2","kind":"target","name":"PCNX2","aka":["pecanex 2","Pecanex-like protein 2","KIAA0435","FLJ11383","PCNXL2"],"tldr":"PCNX2 (Pecanex-like protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H).\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.63, animal model 0.52, genetic association 0.64).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8736","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8736"},{"label":"UniProt A6NKB5","url":"https://www.uniprot.org/uniprotkb/A6NKB5/entry"},{"label":"NCBI Gene 80003","url":"https://www.ncbi.nlm.nih.gov/gene/80003"},{"label":"Ensembl ENSG00000135749","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000135749"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PCNX2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:8736","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8736","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt A6NKB5","url":"https://www.uniprot.org/uniprotkb/A6NKB5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000135749","url":"https://platform.opentargets.org/target/ENSG00000135749/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"hgnc":"HGNC:8736","ensembl":"ENSG00000135749","uniprot":"A6NKB5","entrez":"80003","biology":"May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H). Location: Membrane (UniProt). Locus 1q42.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/pcnx2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}