{"entity":{"id":"pdcd4","kind":"target","name":"PDCD4","aka":["programmed cell death 4","Programmed cell death protein 4","H731"],"tldr":"PDCD4 (Programmed cell death protein 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer.","summary":"Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8763","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8763"},{"label":"UniProt Q53EL6","url":"https://www.uniprot.org/uniprotkb/Q53EL6/entry"},{"label":"NCBI Gene 27250","url":"https://www.ncbi.nlm.nih.gov/gene/27250"},{"label":"Ensembl ENSG00000150593","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000150593"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["lung-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PDCD4","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:8763","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8763","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q53EL6","url":"https://www.uniprot.org/uniprotkb/Q53EL6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PDCD4","url":"https://civicdb.org/features/10573","note":"1 evidence items, 0 assertions, 1 variants; diseases: Lung Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:8763","ensembl":"ENSG00000150593","uniprot":"Q53EL6","entrez":"27250","biology":"Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Location: Nucleus; Cytoplasm (UniProt). Locus 10q25.2 (HGNC).","whereFound":["Lung cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/pdcd4/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"}]}}