{"entity":{"id":"pde3a","kind":"target","name":"PDE3A","aka":["phosphodiesterase 3A","cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A","CGI-PDE"],"tldr":"PDE3A (cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Myeloproliferative neoplasms and Essential thrombocythaemia.","summary":"Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Also has activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signalling pathway.\n\nOpen Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.91, genetic association 0.53, somatic mutation 0.23, clinical 0.96).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8778","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8778"},{"label":"UniProt Q14432","url":"https://www.uniprot.org/uniprotkb/Q14432/entry"},{"label":"NCBI Gene 5139","url":"https://www.ncbi.nlm.nih.gov/gene/5139"},{"label":"Ensembl ENSG00000172572","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000172572"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["myeloproliferative-neoplasms","essential-thrombocythaemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.96. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PDE3A","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:8778","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8778","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q14432","url":"https://www.uniprot.org/uniprotkb/Q14432/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000172572","url":"https://platform.opentargets.org/target/ENSG00000172572/associations","note":"association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: myeloproliferative neoplasm 0.59, essential thrombocythemia 0.58 (GraphQL API, CC0)"}],"hgnc":"HGNC:8778","ensembl":"ENSG00000172572","uniprot":"Q14432","entrez":"5139","biology":"Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Also has activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signalling pathway. E2 stabilises the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling. Location: Membrane; Cytoplasm, cytosol (UniProt). Locus 12p12.2 (HGNC).","whereFound":["Myeloproliferative neoplasms: Open Targets association 0.59 with myeloproliferative neoplasm (MONDO_0020076)","Essential thrombocythaemia: Open Targets association 0.58 with essential thrombocythemia (MONDO_0005029)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/pde3a/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"essential-thrombocythaemia","kind":"cancer","name":"Essential thrombocythaemia (ET)","route":"/cancers/essential-thrombocythaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"}]}}