{"entity":{"id":"pdgfrl","kind":"target","name":"PDGFRL","aka":["platelet derived growth factor receptor like","Platelet-derived growth factor receptor-like protein","PRLTS"],"tldr":"PDGFRL (Platelet-derived growth factor receptor-like protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.","summary":"UniProt has no function text for Q15198; HGNC names it \"platelet derived growth factor receptor like\".\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.30, genetic association 0.47, somatic mutation 0.55, animal model 0.43).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8805","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8805"},{"label":"UniProt Q15198","url":"https://www.uniprot.org/uniprotkb/Q15198/entry"},{"label":"NCBI Gene 5157","url":"https://www.ncbi.nlm.nih.gov/gene/5157"},{"label":"Ensembl ENSG00000104213","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104213"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PDGFRL","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:8805","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8805","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q15198","url":"https://www.uniprot.org/uniprotkb/Q15198/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000104213","url":"https://platform.opentargets.org/target/ENSG00000104213/associations","note":"association with cancer (MONDO_0004992) 0.51; per-cancer scores at or above 0.5: colorectal cancer 0.50 (GraphQL API, CC0)"}],"hgnc":"HGNC:8805","ensembl":"ENSG00000104213","uniprot":"Q15198","entrez":"5157","biology":"UniProt has no function text for Q15198; HGNC names it \"platelet derived growth factor receptor like\". Location: Secreted (UniProt). Locus 8p22 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)"],"targetClass":"other","prevalence":[]},"route":"/targets/pdgfrl/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}