{"entity":{"id":"pdlim5","kind":"target","name":"PDLIM5","aka":["PDZ and LIM domain 5","PDZ and LIM domain protein 5","Enh"],"tldr":"PDLIM5 (PDZ and LIM domain protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1.\n\nOpen Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.61, genetic association 0.64).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:17468","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17468"},{"label":"UniProt Q96HC4","url":"https://www.uniprot.org/uniprotkb/Q96HC4/entry"},{"label":"NCBI Gene 10611","url":"https://www.ncbi.nlm.nih.gov/gene/10611"},{"label":"Ensembl ENSG00000163110","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163110"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PDLIM5","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:17468","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17468","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96HC4","url":"https://www.uniprot.org/uniprotkb/Q96HC4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000163110","url":"https://platform.opentargets.org/target/ENSG00000163110/associations","note":"association with cancer (MONDO_0004992) 0.50; per-cancer scores at or above 0.5: prostate cancer 0.50 (GraphQL API, CC0)"}],"hgnc":"HGNC:17468","ensembl":"ENSG00000163110","uniprot":"Q96HC4","entrez":"10611","biology":"May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Location: Postsynaptic density; Presynapse; Postsynapse; Cytoplasm, cytosol (UniProt). Locus 4q22.3 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.50 with prostate cancer (MONDO_0008315)"],"targetClass":"other","prevalence":[]},"route":"/targets/pdlim5/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}