{"entity":{"id":"pdxnet","kind":"institution","name":"PDX Development and Trial Centers Research Network (PDXNet)","aka":["PDXNet","PDX Network"],"tldr":"A US National Cancer Institute network, started in 2017, that grows patients' tumours in mice to test combinations of cancer drugs before they go into human trials, and shares the models and data with other researchers.","summary":"The NCI launched PDXNet in September 2017 to accelerate translational research using patient-derived xenograft (PDX) datasets, and renewed it in 2023. The network comprises six PDX Development and Trial Centers and the PDX Data Commons and Coordinating Center (PDCCC), and works with the NCI Patient-Derived Model Repository so that data are collected and provided in a standard format; together they test multi-agent treatments in PDX studies and advance them to human clinical trials. The PDCCC, whose team the network names as from The Jackson Laboratory, provides the administrative and computational infrastructure for method standardisation, model sharing and large-scale analysis. The site lists the awards: U24-CA224067 for the coordinating centre, and U54-CA224076, U54-CA224083, U54-CA224070, U54-CA283759, U54-CA283766 and U54-CA283762 for the development and trial centres.","asOf":"2026-11-04","links":[{"label":"PDXNet","url":"https://www.pdxnetwork.org/"},{"label":"PDXNet Data Commons and Coordinating Center","url":"https://www.pdxnetwork.org/pdccc"}],"tags":["research-funding"],"related":["cancer-models"],"cancers":[],"sections":[],"technologies":["pdx-models"],"targets":[],"drugs":[],"companies":[],"institutions":["nci","jackson-laboratory"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":["b-preclinical-models","b-combination-space"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Placed at NCI in Bethesda. The six development and trial centre institutions were not listed on the pages read and are not named; the coordinating centre page's header names Huntsman Cancer Institute and Baylor College of Medicine without saying what role they play, so they are not linked.","The corpus's preclinical-models side table already describes PDXNet in one line; this is its record."],"city":"Bethesda, MD","country":"US","lat":39.003,"lng":-77.104,"institutionType":"consortium","website":"https://www.pdxnetwork.org/","programs":["Six PDX Development and Trial Centers","PDX Data Commons and Coordinating Center (The Jackson Laboratory)","Link to the NCI Patient-Derived Model Repository"]},"route":"/institutions/pdxnet/","neighbours":{"collection":[{"id":"cancer-models","kind":"collection","name":"Cancer Models (PDCM Finder) & HCMI","route":"/collections/cancer-models/"}],"technology":[{"id":"pdx-models","kind":"technology","name":"Patient-derived xenografts","route":"/technologies/pdx-models/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"},{"id":"jackson-laboratory","kind":"institution","name":"The Jackson Laboratory Cancer Center","route":"/institutions/jackson-laboratory/"}],"bottleneck":[{"id":"b-preclinical-models","kind":"bottleneck","name":"Lab models that fail to predict what happens in patients","route":"/bottlenecks/b-preclinical-models/"},{"id":"b-combination-space","kind":"bottleneck","name":"Too many combinations to test","route":"/bottlenecks/b-combination-space/"}]}}