{"entity":{"id":"pdzd2","kind":"target","name":"PDZD2","aka":["PDZ domain containing 2","PDZ domain-containing protein 2","KIAA0300","PDZK3"],"tldr":"PDZD2 (PDZ domain-containing protein 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.","summary":"UniProt has no function text for O15018; HGNC names it \"PDZ domain containing 2\".\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pleural Mesothelioma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18486","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18486"},{"label":"UniProt O15018","url":"https://www.uniprot.org/uniprotkb/O15018/entry"},{"label":"NCBI Gene 23037","url":"https://www.ncbi.nlm.nih.gov/gene/23037"},{"label":"Ensembl ENSG00000133401","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000133401"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["mesothelioma","pleural-mesothelioma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PDZD2","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:18486","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18486","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15018","url":"https://www.uniprot.org/uniprotkb/O15018/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen PDZD2","url":"https://www.intogen.org/search?gene=PDZD2","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:18486","ensembl":"ENSG00000133401","uniprot":"O15018","entrez":"23037","biology":"UniProt has no function text for O15018; HGNC names it \"PDZ domain containing 2\". Location: Nucleus; Cytoplasm; Endoplasmic reticulum; Secreted (UniProt). Locus 5p13.3 (HGNC).","whereFound":["Mesothelioma: IntOGen driver in 1 cohort (PLMESO)","Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/pdzd2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"pleural-mesothelioma","kind":"cancer","name":"Pleural mesothelioma","route":"/cancers/pleural-mesothelioma/"}]}}