{"entity":{"id":"peg3","kind":"target","name":"PEG3","aka":["paternally expressed 3","Paternally-expressed gene 3 protein","ZKSCAN22","KIAA0287","ZNF904","ZSCAN24"],"tldr":"PEG3 (Paternally-expressed gene 3 protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.","summary":"Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8826","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8826"},{"label":"UniProt Q9GZU2","url":"https://www.uniprot.org/uniprotkb/Q9GZU2/entry"},{"label":"NCBI Gene 5178","url":"https://www.ncbi.nlm.nih.gov/gene/5178"},{"label":"Ensembl ENSG00000198300","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198300"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PEG3","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:8826","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8826","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9GZU2","url":"https://www.uniprot.org/uniprotkb/Q9GZU2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen PEG3","url":"https://www.intogen.org/search?gene=PEG3","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:8826","ensembl":"ENSG00000198300","uniprot":"Q9GZU2","entrez":"5178","biology":"Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumour suppressing activity in glioma cells. Location: Nucleus; Cytoplasm (UniProt). Locus 19q13.43 (HGNC).","whereFound":["Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/peg3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}]}}