{"entity":{"id":"phlpp2","kind":"target","name":"PHLPP2","aka":["PH domain and leucine rich repeat protein phosphatase 2","PHLPPL","PPM3B"],"tldr":"PHLPP2 is a phosphatase that switches AKT off; it is lost in most colorectal cancers, which leaves the survival pathway on.","summary":"UniProt describes PHLPP2 as the phosphatase that removes the activating Ser-473 phosphate from AKT1 and equivalent sites on PKC, and records that its protein is lost in about four in five colorectal cancers. It is a case where the protein, not the transcript, tells the story: a PI3K/AKT activation state that RNA alone cannot see.","asOf":"2026-09-24","links":[{"label":"HGNC HGNC:29149","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29149"},{"label":"UniProt Q6ZVD8","url":"https://www.uniprot.org/uniprotkb/Q6ZVD8/entry"}],"tags":["cansim-terms"],"related":[],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["pi3k-akt-mtor"],"terms":["co-amplification","cancer-ai-vocabulary","pathway-activation-state","mrna-protein-concordance"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme."],"provenance":{"editedBy":"OnCo CanSim terms wave (HGNC REST, UniProt REST)","editedOn":"2026-09-24","note":"CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme"},"symbol":"PHLPP2","role":["tumour-suppressor","biomarker"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:29149","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29149","note":"approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)"},{"label":"UniProt Q6ZVD8","url":"https://www.uniprot.org/uniprotkb/Q6ZVD8/entry","note":"protein name, function and tissue specificity text (REST API, 2026-09-24)"}],"specificitySources":[],"hgnc":"HGNC:29149","ensembl":"ENSG00000040199","uniprot":"Q6ZVD8","entrez":"23035","biology":"Protein phosphatase that dephosphorylates Ser-473 of AKT1 and hydrophobic-motif sites of PKC isoforms; expression lost or significantly decreased in about 80 percent of tested colorectal tumours at the protein level (UniProt Q6ZVD8).","whereFound":["Locus 16q22.2 (HGNC)."],"targetClass":"enzyme","prevalence":[]},"route":"/targets/phlpp2/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"pathway":[{"id":"pi3k-akt-mtor","kind":"pathway","name":"PI3K / AKT / mTOR","route":"/pathways/pi3k-akt-mtor/"}],"term":[{"id":"cancer-ai-vocabulary","kind":"term","name":"Cancer AI vocabulary (CanSim terms map)","route":"/terms/cancer-ai-vocabulary/"},{"id":"co-amplification","kind":"term","name":"Co-amplification and the 17q12 HER2 amplicon","route":"/terms/co-amplification/"},{"id":"mrna-protein-concordance","kind":"term","name":"mRNA to protein concordance","route":"/terms/mrna-protein-concordance/"},{"id":"pathway-activation-state","kind":"term","name":"Pathway activation state (phosphosignalling)","route":"/terms/pathway-activation-state/"}]}}