{"entity":{"id":"pik3cb","kind":"target","name":"PIK3CB","aka":["phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta","Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform","PIK3C1"],"tldr":"PIK3CB is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signalling cascades involved in cell growth, survival, proliferation, motility and morphology.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Doxorubicin. Open Targets scores its association with cancer at 0.82 (direct and indirect evidence; datatypes clinical 0.67, affected pathway 0.86, literature 0.99, genetic association 0.31, somatic mutation 0.86, animal model 0.39). IntOGen calls it a driver in 5 cohorts (4 activating, 1 loss-of-function), covering Bladder Urothelial Carcinoma, Glioblastoma Multiforme, Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8976","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8976"},{"label":"UniProt P42338","url":"https://www.uniprot.org/uniprotkb/P42338/entry"},{"label":"NCBI Gene 5291","url":"https://www.ncbi.nlm.nih.gov/gene/5291"},{"label":"Ensembl ENSG00000051382","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000051382"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["breast-cancer","sarcoma","prostate","urothelial","skin-cancer","lung-cancer","ovarian","head-and-neck"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.67; IntOGen calls it an activating (Act) driver in 4 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PIK3CB","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:8976","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8976","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P42338","url":"https://www.uniprot.org/uniprotkb/P42338/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PIK3CB","url":"https://civicdb.org/features/4285","note":"2 evidence items, 0 assertions, 2 variants; diseases: Sarcoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000051382","url":"https://platform.opentargets.org/target/ENSG00000051382/associations","note":"association with cancer (MONDO_0004992) 0.82; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.51, ovarian cancer 0.51, head and neck squamous cell carcinoma 0.50, skin cancer 0.55, breast cancer 0.67, lung cancer 0.54 (GraphQL API, CC0)"},{"label":"IntOGen PIK3CB","url":"https://www.intogen.org/search?gene=PIK3CB","note":"driver in 5 cohorts (Act 4, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:8976","ensembl":"ENSG00000051382","uniprot":"P42338","entrez":"5291","biology":"Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signalling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G protein-coupled receptor (GPCR) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signalling pathways for stable platelet adhesion and aggregation. Location: Cytoplasm; Nucleus (UniProt). Locus 3q22.3 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.67 with breast cancer (MONDO_0007254)","Sarcomas: CIViC evidence names this disease","Prostate cancer: IntOGen driver in 2 cohorts (PRAD)","Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)","Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/pik3cb/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}