{"entity":{"id":"plag1","kind":"target","name":"PLAG1","aka":["PLAG1 zinc finger","Zinc finger protein PLAG1","ZNF912"],"tldr":"PLAG1 (Zinc finger protein PLAG1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Melanoma and Oral cavity cancer.","summary":"Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas.\n\nOpen Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.33, somatic mutation 0.87). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Invasive Breast Carcinoma, Cutaneous Melanoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9045","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9045"},{"label":"UniProt Q6DJT9","url":"https://www.uniprot.org/uniprotkb/Q6DJT9/entry"},{"label":"NCBI Gene 5324","url":"https://www.ncbi.nlm.nih.gov/gene/5324"},{"label":"Ensembl ENSG00000181690","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000181690"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["breast-cancer","melanoma","oral-cavity-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PLAG1","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:9045","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9045","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6DJT9","url":"https://www.uniprot.org/uniprotkb/Q6DJT9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000181690","url":"https://platform.opentargets.org/target/ENSG00000181690/associations","note":"association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: breast cancer 0.57, oral cavity cancer 0.52 (GraphQL API, CC0)"},{"label":"IntOGen PLAG1","url":"https://www.intogen.org/search?gene=PLAG1","note":"driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:9045","ensembl":"ENSG00000181690","uniprot":"Q6DJT9","entrez":"5324","biology":"Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumour in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukaemia. Location: Nucleus (UniProt). Locus 8q12.1 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.57 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA)","Melanoma: IntOGen driver in 1 cohort (SKCM)","Oral cavity cancer: Open Targets association 0.52 with oral cavity cancer (MONDO_0005515)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/plag1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"oral-cavity-cancer","kind":"cancer","name":"Oral cavity cancer (mouth and tongue)","route":"/cancers/oral-cavity-cancer/"}]}}